There's an article in Time about the hits Michelle Obama took to her career in service of marrying and having a family with Barack.
It makes me a little queasy that the article is titled "Michelle Obama's Savvy Sacrifice," since it implies that Michelle made a calculating and clever move, letting Barack's career take precedence over her own. But who knows, maybe she'd be the politician by now if she'd stayed on her career track.
Most women who go down this path aren't setting themselves up to be First Lady. They're setting themselves up for letting their degree waste away in a filing cabinet, and possibly financial insecurity after divorce or their husband's death.